Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 8/20 | 0.56 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12184137 | 1.00 | PRCP (0.56) | PRCPKIF11GRM5SCN4ANT5E | |
| SCHEMBL14749294 | 0.92 | PRCP (0.47) | PRCPGRM5NTRK1KDM4EALDH1A1 | |
| SCHEMBL14737395 | 0.90 | PRCP (0.56) | PRCPGRM5NT5ESLC6A9NAMPT | |
| SCHEMBL14736813 | 0.90 | PRCP (0.56) | PRCPGRM5NT5ESLC6A9NAMPT | |
| SCHEMBL12183916 | 0.90 | PRCP (0.58) | PRCPGRM5NT5ESLC6A9NAMPT | |
| SCHEMBL14749314 | 0.90 | PRCP (0.58) | PRCPGRM5NT5ESLC6A9NAMPT | |
| SCHEMBL12184583 | 0.85 | PRCP (0.52) | PRCPNT5E | |
| SCHEMBL14752639 | 0.83 | PRCP (0.52) | PRCPGRM5ALDH1A1 | |
| SCHEMBL14737070 | 0.82 | PRCP (0.54) | PRCPGRM5NTRK1KDM4E | |
| SCHEMBL14749284 | 0.81 | PRCP (0.49) | PRCPGRM5NTRK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146354-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-11-24 | — | — | WO | disclosed |