Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12185065 | 0.96 | HIF1A (0.48) | ALDH1A1HIF1AEPAS1CHRM3HDAC6 | |
| SCHEMBL12184619 | 0.93 | KCNH2 (0.48) | ALDH1A1HIF1AEPAS1MEN1KMT2A | |
| SCHEMBL12184585 | 0.92 | KCNH2 (0.45) | ALDH1A1HIF1AEPAS1CHRM3OPRL1 | |
| SCHEMBL12184988 | 0.91 | CHRM4 (0.52) | HIF1AEPAS1CHRM4POLBGAA | |
| SCHEMBL12184387 | 0.91 | KCNH2 (0.48) | ALDH1A1HIF1AEPAS1CHRM3GAA | |
| SCHEMBL12184740 | 0.91 | HIF1A (0.43) | ALDH1A1HIF1AEPAS1CHRM3HDAC6 | |
| SCHEMBL12184868 | 0.90 | DRD4 (0.47) | ALDH1A1HIF1AEPAS1CHRM4CHRM3 | |
| SCHEMBL12184984 | 0.90 | HIF1A (0.56) | ALDH1A1HIF1AEPAS1CHRM3GAA | |
| SCHEMBL12184627 | 0.90 | TSHR (0.57) | MEN1KMT2AOPRL1PRKAB2PRKAG1 | |
| SCHEMBL12184758 | 0.89 | HIF1A (0.43) | ALDH1A1HIF1AEPAS1CHRM3OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011142359-A1 | SPIRO COMPOUND AND DRUG FOR ACTIVATING ADIPONECTIN RECEPTOR | 日産化学工業株式会社 (JP) | 2011-11-17 | — | — | WO | disclosed |