Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 5/20 | 0.69 |
| ▸ | DRD4 | P21917 | 8/20 | 0.41 |
| ▸ | DRD2 | P14416 | 7/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 6/20 | 0.38 |
| ▸ | CCR5 | P51681 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14686523 | 0.82 | PRCP (1.00) | PRCPDRD4DRD2DRD3CCR5 | |
| SCHEMBL14686462 | 0.73 | PRCP (0.84) | PRCPDRD4DRD2DRD3CYP1A2 | |
| SCHEMBL14686592 | 0.70 | PRCP (0.78) | PRCPDRD4DRD2DRD3CYP1A2 | |
| SCHEMBL12186005 | 0.67 | PRCP (0.74) | PRCPDRD4DRD2DRD3CYP1A2 | |
| SCHEMBL1388434 | 0.67 | DRD4 (0.60) | PRCPDRD4DRD2DRD3MEN1 | |
| SCHEMBL14686651 | 0.66 | PRCP (0.76) | PRCPDRD4DRD2DRD3CYP1A2 | |
| SCHEMBL12185619 | 0.66 | PRCP (0.79) | PRCPDRD4DRD2DRD3CYP1A2 | |
| SCHEMBL5454539 | 0.65 | PRCP (0.51) | PRCPDRD4DRD2DRD3CCR5 | |
| SCHEMBL5445584 | 0.65 | PRCP (0.51) | PRCPDRD4DRD2MCHR1DRD3 | |
| SCHEMBL12185580 | 0.64 | PRCP (1.00) | PRCPDRD4DRD2DRD3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011143057-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-11-17 | — | — | WO | disclosed |