Indole

Indole

SCHEMBL121870

[N].c1ccc2[nH]ccc2c1

nearest known ligand 0.94

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 7/20 0.94
CA1 P00915 2/20 0.94
CA4 P22748 2/20 0.94
CA6 P23280 2/20 0.94
TRPA1 O75762 1/20 0.94
CA2 P00918 1/20 0.94
ITGB2 P05107 1/20 0.94
ICAM1 P05362 1/20 0.94
ITGAL P20701 1/20 0.94
ADK P55263 1/20 0.94
NPC1 O15118 1/20 0.50
ALDH1A1 P00352 1/20 0.46
CYP2A6 P11509 3/20 0.44
NR4A2 P43354 2/20 0.44
CMA1 P23946 1/20 0.44
F7 P08709 1/20 0.44
LTA4H P09960 1/20 0.44
F3 P13726 1/20 0.44
PARP1 P09874 1/20 0.44
TYR P14679 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indole SCHEMBL31471985 0.97 AHR (0.90) AHRCA1CA4CA6TRPA1
Indole SCHEMBL30250492 0.97
Indole SCHEMBL30463845 0.97
Indole SCHEMBL29352896 0.97
Indole SCHEMBL698 0.97
Indole SCHEMBL28071644 0.97 AHR (1.00) AHRCA1CA4CA6TRPA1
Indole SCHEMBL1160186 0.97 AHR (1.00) AHRCA1CA4CA6TRPA1
Indole SCHEMBL23886438 0.94 AHR (0.94) AHRCA1CA4CA6TRPA1
Indole SCHEMBL3538342 0.94 AHR (0.94) AHRCA1CA4CA6TRPA1
Indole SCHEMBL2000860 0.94 AHR (0.94) AHRCA1CA4CA6TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4646 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4602064-B1 METHOD OF MANUFACTURING A PEPTIDE WITH A LYSINE DERIVATIVE BACHEM HOLDING AG (CH) 2026-05-13 EP claimed
US-20250304573-A1 LYSERGIC ACID DERIVATIVES AND METHODS UNIV FLORIDA STATE RES FOUND INC (US) 2025-10-02 US claimed
EP-4602064-A1 METHOD OF MANUFACTURING A PEPTIDE WITH A LYSINE DERIVATIVE Bachem Holding AG (CH) 2025-08-20 EP claimed
EP-3969457-B1 METHODS OF PREPARING MACROCYCLIC INDOLES BROAD INST INC (US) 2025-08-13 EP claimed
US-12338250-B2 Methods of preparing macrocyclic indoles THE BROAD INSTITUTE, INC. (US) 2025-06-24 US claimed
CN-119731161-A Lysergic acid derivatives and methods 佛罗里达州立大学研究基金会有限公司 2025-03-28 CN claimed
EP-4522601-A1 LYSERGIC ACID DERIVATIVES AND METHODS The Florida State University Research Foundation, Inc. (US) 2025-03-19 EP claimed
US-12152041-B2 Macrocyclic fluorine substituted indole derivatives THE BROAD INSTITUTE, INC. (US) 2024-11-26 US claimed
US-20240216339-A1 METHODS OF TREATING NEUROPSYCHIATRIC DISORDERS GILGAMESH PHARMACEUTICALS, INC. (US) 2024-07-04 US claimed
CN-115806555-B Indoloazepinone derivatives, their preparation and their use for controlling plant viruses, for killing parasites and for killing bacteria 南开大学 2024-05-28 CN claimed
EP-0131007-A1 GnRH AGONISTS. SALK INST FOR BIOLOGICAL STUDI (US) 1985-01-16 EP claimed
EP-0125290-A1 PEPTIDES AFFECTING GONADAL FUNCTION. SALK INST FOR BIOLOGICAL STUDI (US) 1984-11-21 EP claimed
EP-0122712-A2 GnRH antagonists THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1984-10-24 EP claimed
WO-1984002341-A1 GnRH AGONISTS SALK INST FOR BIOLOGICAL STUDI (US) 1984-06-21 WO claimed
WO-1984001771-A1 PEPTIDES AFFECTING GONADAL FUNCTION SALK INST FOR BIOLOGICAL STUDI (US) 1984-05-10 WO claimed
EP-0107963-A1 Indole derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-05-09 EP claimed
US-4342671-A FOR TREATMENT OF ACROMEGALY AND DIABETES, INHIBITS RELEASE OF GROWTH HORMONE AMERICAN HOME PRODUCTS CORPORATION (US) 1982-08-03 US claimed
EP-0004664-B1 A PROCESS FOR PREPARING LYSERGOL DERIVATIVES Corvi Mora, Enrico (IT) 1982-04-14 EP claimed
US-4232157-A Process for preparing lysergol derivatives ISTITUTO CHEMIOTERAPICO DI LODI SPA, A CORP OF ITALY (IT) 1980-11-04 US claimed
EP-0004664-A1 A process for preparing lysergol derivatives Corvi Mora, Enrico (IT) 1979-10-17 EP claimed