Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 14/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 14/20 | 1.00 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.67 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.67 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12632023 | 1.00 | MEN1 (1.00) | MEN1KMT2ATNNI3TNNT2TNNC1 | |
| SCHEMBL29351495 | 1.00 | MEN1 (1.00) | MEN1KMT2ATNNI3TNNT2TNNC1 | |
| SCHEMBL18726125 | 0.90 | MEN1 (0.82) | MEN1KMT2ATNNI3TNNT2TNNC1 | |
| SCHEMBL18726123 | 0.90 | MEN1 (0.82) | MEN1KMT2ATNNI3TNNT2TNNC1 | |
| SCHEMBL20529074 | 0.88 | MEN1 (0.78) | MEN1KMT2ATNNI3TNNT2TNNC1 | |
| SCHEMBL29695409 | 0.88 | MEN1 (0.78) | MEN1KMT2ATNNI3TNNT2TNNC1 | |
| SCHEMBL20529024 | 0.83 | MEN1 (0.70) | MEN1KMT2ATNNI3TNNT2TNNC1 | |
| SCHEMBL29695414 | 0.83 | MEN1 (0.70) | MEN1KMT2ATNNI3TNNT2TNNC1 | |
| SCHEMBL20529015 | 0.81 | MEN1 (0.68) | MEN1KMT2ATNNI3TNNT2TNNC1 | |
| SCHEMBL20529117 | 0.81 | MEN1 (0.68) | MEN1KMT2ATNNI3TNNT2TNNC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3362448-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | Inventiva (FR) | 2018-08-22 | — | — | EP | disclosed |
| WO-2017064277-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | INVENTIVA (FR) | 2017-04-20 | — | — | WO | disclosed |
| US-7893096-B2 | For example, N-methyl-4-[(2-{[2-(1-methylethyl)phenyl]amino}-1 H-benzimidazol-5-yl)oxy]pyridine-2-carboxamide; administering the compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2011-02-22 | — | — | US | disclosed |