Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 3/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 3/20 | 0.33 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15849817 | 1.00 | KIT (0.43) | KITMAP4K4PIK3CDKDRADK | |
| SCHEMBL20997359 | 0.83 | KDR (0.35) | PIK3CDKDREGLN1 | |
| SCHEMBL24269588 | 0.82 | KDR (0.34) | KDR | |
| SCHEMBL24269784 | 0.82 | KDR (0.34) | KDR | |
| SCHEMBL18409208 | 0.74 | BTK (0.31) | KDR | |
| SCHEMBL3805725 | 0.74 | TLR9 (0.46) | MAP4K4 | |
| SCHEMBL23810485 | 0.73 | BTK (0.32) | — | |
| SCHEMBL13075093 | 0.68 | MAP4K4 (0.47) | KITMAP4K4 | |
| SCHEMBL275263 | 0.68 | MAP4K4 (0.47) | KITMAP4K4KDRPI4KAPI4K2B | |
| SCHEMBL27315074 | 0.66 | MAP4K4 (0.41) | MAP4K4PIK3CDKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120232054-A1 | PYRROLOTRIAZINE COMPOUNDS | LOCUS PHARMACEUTICALS, INC. (US) | 2012-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232054-A1 | PYRROLOTRIAZINE COMPOUNDS | BTK, SYK, ZAP70 | KIT 2934/4885MAP4K4 1324/4885PIK3CD 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.