Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.40 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.40 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.40 |
| ▸ | CXCL10 | P02778 | 1/20 | 0.38 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.38 |
| ▸ | CCL2 | P13500 | 1/20 | 0.38 |
| ▸ | CCL5 | P13501 | 1/20 | 0.38 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CD69 | Q07108 | 1/20 | 0.35 |
| ▸ | B4GALT1 | P15291 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ASGR1 | P07306 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL730739 | 0.89 | MAPK1 (0.65) | MAPK1MEN1KMT2AALDH1A1THRB | |
| SCHEMBL24822648 | 0.89 | MAPK1 (0.65) | MAPK1MEN1KMT2AALDH1A1THRB | |
| SCHEMBL2292636 | 0.89 | MAPK1 (0.65) | MAPK1MEN1KMT2AALDH1A1THRB | |
| SCHEMBL23133631 | 0.89 | MAPK1 (0.65) | MAPK1MEN1KMT2AALDH1A1THRB | |
| SCHEMBL13671169 | 0.89 | MAPK1 (0.65) | MAPK1MEN1KMT2AALDH1A1THRB | |
| SCHEMBL23618308 | 0.89 | MAPK1 (0.65) | MAPK1MEN1KMT2AALDH1A1THRB | |
| SCHEMBL15260475 | 0.89 | MAPK1 (0.65) | MAPK1MEN1KMT2AALDH1A1THRB | |
| SCHEMBL24531188 | 0.89 | MAPK1 (0.65) | MAPK1MEN1KMT2AALDH1A1THRB | |
| SCHEMBL10261426 | 0.89 | MAPK1 (0.65) | MAPK1MEN1KMT2AALDH1A1THRB | |
| SCHEMBL12648681 | 0.89 | MAPK1 (0.65) | MAPK1MEN1KMT2AALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130109817-A1 | Modified Polymers for Delivery of Polynucleotides, Method of Manufacture, and Methods of Use Thereof | MERSANA THERAPEUTICS, INC. (US) | 2013-05-02 | — | — | US | disclosed |
| US-20130109817-A1 | Modified Polymers for Delivery of Polynucleotides, Method of Manufacture, and Methods of Use Thereof | MERSANA THERAPEUTICS, INC. (US) | 2013-05-02 | — | — | US | disclosed |
| US-8349308-B2 | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof | MERSANA THERAPEUTICS, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-8349308-B2 | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof | MERSANA THERAPEUTICS, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-20110243880-A1 | MODIFIED POLYMERS FOR DELIVERY OF POLYNUCLEOTIDES, METHOD OF MANUFACTURE, AND METHODS OF USE THEREOF | MERSANA THERAPEUTICS, INC. (US) | 2011-10-06 | — | — | US | disclosed |
| US-20110243880-A1 | MODIFIED POLYMERS FOR DELIVERY OF POLYNUCLEOTIDES, METHOD OF MANUFACTURE, AND METHODS OF USE THEREOF | MERSANA THERAPEUTICS, INC. (US) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110243880-A1 | MODIFIED POLYMERS FOR DELIVERY OF POLYNUCLEOTIDES, METHOD OF MANUFACTURE, AND METHODS OF USE THEREOF | ZYX, NSUN3, NSUN2 | MAPK1 4800/4885MEN1 2569/4885KMT2A 3258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.