Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 5/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.38 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4257822 | 0.85 | SCN9A (0.43) | CSF1RLCKKDRSRCINSR | |
| SCHEMBL12192469 | 0.81 | CSF1R (0.69) | CSF1RLCKKDRSRCINSR | |
| SCHEMBL1358527 | 0.79 | HDAC3 (0.58) | CSF1RLCKKDRSRCKIT | |
| SCHEMBL4257816 | 0.75 | BTK (0.42) | CSF1RLCKKDRSRCINSR | |
| SCHEMBL12465329 | 0.75 | P2RY14 (0.53) | CSF1RLCKKDRSRCKIT | |
| SCHEMBL4421974 | 0.75 | CSF1R (0.52) | CSF1RLCKKDRSRCKIT | |
| SCHEMBL22025295 | 0.73 | PTGS1 (0.64) | KITBTKPTGS1 | |
| SCHEMBL12464982 | 0.72 | HDAC3 (0.47) | CSF1RLCKKDRSRCKIT | |
| SCHEMBL4250376 | 0.72 | CSF1R (0.67) | CSF1RLCKKDRSRCINSR | |
| SCHEMBL374471 | 0.71 | PTGS1 (0.70) | CSF1RLCKKDRSRCKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899329-B1 | PYRIMIDINE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2011-10-05 | — | — | EP | disclosed |