Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5531970 | 0.91 | PDE5A (0.63) | PDE5A | |
| SCHEMBL12194947 | 0.88 | PDE5A (0.65) | PDE5A | |
| SCHEMBL12194910 | 0.88 | PDE5A (0.78) | PDE5A | |
| SCHEMBL6409672 | 0.85 | PDE5A (0.79) | PDE5A | |
| SCHEMBL14599799 | 0.84 | PDE5A (0.72) | PDE5A | |
| SCHEMBL6409755 | 0.80 | PDE5A (0.70) | PDE5A | |
| SCHEMBL5530176 | 0.79 | PDE5A (0.67) | PDE5A | |
| SCHEMBL6407149 | 0.79 | PDE5A (1.00) | PDE5A | |
| SCHEMBL6407697 | 0.79 | PDE5A (0.67) | PDE5A | |
| SCHEMBL5528591 | 0.78 | PDE5A (0.60) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110245503-A1 | ENANTIOSELECTIVE SYNTHESIS OF ASYMMETRIC BETA-CARBOLINE INTERMEDIATES | UNIVERSIDAD DE TALCA (CL) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245503-A1 | ENANTIOSELECTIVE SYNTHESIS OF ASYMMETRIC BETA-CARBOLINE INTERMEDIATES | PDE1B, PDE3B, PDE1A | PDE5A 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.