Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 15/20 | 0.69 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2476259 | 0.99 | KCNA5 (0.70) | KCNA5KCND3KCNH2KCNN4CYP3A4 | |
| SCHEMBL2493519 | 0.99 | KCNA5 (0.70) | KCNA5KCND3KCNH2KCNN4CYP3A4 | |
| SCHEMBL2472879 | 0.99 | KCNA5 (0.70) | KCNA5KCND3KCNH2KCNN4CYP3A4 | |
| SCHEMBL2493518 | 0.99 | KCNA5 (0.70) | KCNA5KCND3KCNH2KCNN4CYP3A4 | |
| SCHEMBL12194982 | 0.97 | KCNA5 (0.70) | KCNA5KCND3KCNH2CYP3A4CYP3A5 | |
| SCHEMBL12052091 | 0.93 | KCNA5 (0.60) | KCNA5KCND3KCNH2KCNN4CYP3A4 | |
| SCHEMBL12052093 | 0.92 | KCNA5 (0.61) | KCNA5KCND3KCNH2KCNN4CYP3A4 | |
| SCHEMBL12052105 | 0.90 | KCNA5 (0.61) | KCNA5KCND3KCNH2KCNN4CYP3A4 | |
| SCHEMBL2493621 | 0.90 | KCNA5 (0.66) | KCNA5KCND3KCNH2KDM4EALDH1A1 | |
| SCHEMBL12195879 | 0.90 | KCNA5 (0.66) | KCNA5KCND3KCNH2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994029-B1 | POTASSIUM CHANNEL INHIBITORS | MERCK SHARP & DOHME (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2007089678-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |