Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.35 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1217998 | 0.92 | HSP90AA1 (0.50) | HSP90AA1MAOAMAOBCASP3NAMPT | |
| SCHEMBL1218354 | 0.91 | HSP90AA1 (0.49) | HSP90AA1MAOAMAOBCASP3NAMPT | |
| SCHEMBL1219038 | 0.91 | HSP90AA1 (0.49) | HSP90AA1POLBNR3C2ALDH1A1HSP90AB1 | |
| SCHEMBL1219555 | 0.91 | HSP90AA1 (0.52) | HSP90AA1POLBNR3C2ALDH1A1HSP90AB1 | |
| SCHEMBL1219113 | 0.90 | HSP90AA1 (0.47) | HSP90AA1MAOAMAOBCASP3NAMPT | |
| SCHEMBL1219298 | 0.90 | HSP90AA1 (0.48) | HSP90AA1POLBNR3C2ALDH1A1HSP90AB1 | |
| SCHEMBL2080651 | 0.87 | HSP90AA1 (0.51) | HSP90AA1NAMPTPOLBNR3C2ALDH1A1 | |
| SCHEMBL1219568 | 0.87 | HSP90AA1 (0.51) | HSP90AA1POLBNR3C2ALDH1A1HSP90AB1 | |
| SCHEMBL2079076 | 0.87 | HSP90AA1 (0.49) | HSP90AA1NAMPTPOLBNR3C2ALDH1A1 | |
| SCHEMBL1219294 | 0.86 | HSP90AA1 (0.47) | HSP90AA1NR3C2ALDH1A1HSP90AB1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028485-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | EGGENWEILER HANS-MICHAEL | 2011-02-03 | — | — | US | claimed |
| US-20090325974-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | MERCK PATENT GESELLSCHAFT (DE) | 2009-12-31 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325974-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885MAOA 4236/4885MAOB 4145/4885 |
| US-20110028485-A1 | 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885MAOA 4236/4885MAOB 4145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.