Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | STAT6 | P42226 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14233186 | 0.94 | TUBB1 (0.52) | TUBB1GLAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL58604 | 0.94 | TUBB1 (0.52) | TUBB1GLAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL26607783 | 0.93 | TUBB1 (0.53) | TUBB1GLAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL13681860 | 0.92 | TUBB1 (0.44) | TUBB1GLAALDH1A1SMN1; SMN2KDM4E | |
| Hemiasterlin SCHEMBL13203800 | 0.87 | TUBB1 (0.61) | TUBB1GLAALDH1A1SMN1; SMN2KDM4E | |
| Hemiasterlin SCHEMBL22692376 | 0.87 | TUBB1 (0.61) | TUBB1GLAALDH1A1SMN1; SMN2KDM4E | |
| Hemiasterlin SCHEMBL14115433 | 0.87 | TUBB1 (0.61) | TUBB1GLAALDH1A1SMN1; SMN2KDM4E | |
| Hemiasterlin SCHEMBL57334 | 0.87 | TUBB1 (0.61) | TUBB1GLAALDH1A1SMN1; SMN2KDM4E | |
| Hemiasterlin SCHEMBL57313 | 0.87 | TUBB1 (0.61) | TUBB1GLAALDH1A1SMN1; SMN2KDM4E | |
| Hemiasterlin SCHEMBL4173 | 0.87 | TUBB1 (0.61) | TUBB1GLAALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2374454-A1 | Hemiasterlin derivatives and uses thereof in the treatment of cancer | Eisai R&D Management Co., Ltd. (JP) | 2011-10-12 | — | — | EP | disclosed |