Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.46 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4103735 | 0.87 | GRM5 (0.52) | GRM5NPC1RAB9AHCAR3FFAR2 | |
| SCHEMBL12201477 | 0.87 | GRM5 (0.52) | GRM5NPC1RAB9AHCAR3FFAR2 | |
| SCHEMBL2668326 | 0.86 | GRM5 (0.54) | GRM5NPC1RAB9AHCAR3FFAR2 | |
| SCHEMBL4114224 | 0.82 | GRM5 (0.50) | GRM5NPC1RAB9AHCAR3FFAR2 | |
| SCHEMBL4109054 | 0.81 | GRM5 (0.49) | GRM5NPC1RAB9AHCAR3CXCR2 | |
| SCHEMBL2520163 | 0.81 | GRM5 (0.49) | GRM5NPC1RAB9AHCAR3CXCR2 | |
| SCHEMBL2513021 | 0.79 | GRM5 (0.46) | GRM5FFAR2POLBMAPK1 | |
| SCHEMBL4103721 | 0.77 | GRM5 (0.47) | GRM5NPC1RAB9AHCAR3CXCR2 | |
| SCHEMBL4114293 | 0.77 | GRM5 (0.46) | GRM5NPC1RAB9AHCAR3CXCR2 | |
| SCHEMBL2657224 | 0.74 | GCK (0.65) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034822-B2 | Glucokinase activators | TAKEDA SAN DIEGO, INC. (US) | 2011-10-11 | — | — | US | disclosed |