Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58524 | 1.00 | TUBB1 (0.40) | TUBB1SMN1; SMN2CTSBCTSLCTSS | |
| SCHEMBL89012 | 0.87 | TUBB1 (0.48) | TUBB1 | |
| SCHEMBL58116 | 0.87 | TUBB1 (0.48) | TUBB1 | |
| SCHEMBL57773 | 0.87 | TUBB1 (0.48) | TUBB1 | |
| SCHEMBL12201369 | 0.87 | TUBB1 (0.42) | TUBB1 | |
| SCHEMBL14593274 | 0.87 | TUBB1 (0.48) | TUBB1 | |
| SCHEMBL58781 | 0.79 | TUBB1 (0.56) | TUBB1SMN1; SMN2CTSBCTSLCTSS | |
| SCHEMBL13682030 | 0.79 | TUBB1 (0.56) | TUBB1SMN1; SMN2CTSBCTSLCTSS | |
| SCHEMBL58344 | 0.78 | TUBB1 (0.67) | TUBB1SMN1; SMN2CTSBCTSLCTSS | |
| SCHEMBL13682076 | 0.78 | TUBB1 (0.67) | TUBB1SMN1; SMN2CTSBCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2374454-A1 | Hemiasterlin derivatives and uses thereof in the treatment of cancer | Eisai R&D Management Co., Ltd. (JP) | 2011-10-12 | — | — | EP | disclosed |