Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.60 |
| ▸ | ELANE | P08246 | 3/20 | 0.35 |
| ▸ | STAT6 | P42226 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP4 | P49662 | 1/20 | 0.30 |
| ▸ | CASP5 | P51878 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | CASP9 | P55211 | 1/20 | 0.30 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.30 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14592521 | 1.00 | TUBB1 (0.60) | TUBB1ELANESTAT6CYP3A4CYP2D6 | |
| SCHEMBL58979 | 1.00 | TUBB1 (0.60) | TUBB1ELANESTAT6CYP3A4CYP2D6 | |
| SCHEMBL16316203 | 0.99 | TUBB1 (0.59) | TUBB1ELANESTAT6CYP3A4CYP2D6 | |
| SCHEMBL18421085 | 0.99 | TUBB1 (0.59) | TUBB1ELANESTAT6CYP3A4CYP2D6 | |
| SCHEMBL18421084 | 0.99 | TUBB1 (0.59) | TUBB1ELANESTAT6CYP3A4CYP2D6 | |
| SCHEMBL58832 | 0.99 | TUBB1 (0.59) | TUBB1ELANESTAT6CYP3A4CYP2D6 | |
| SCHEMBL13681898 | 0.99 | TUBB1 (0.59) | TUBB1ELANESTAT6CYP3A4CYP2D6 | |
| SCHEMBL13681981 | 0.99 | TUBB1 (0.59) | TUBB1ELANESTAT6CYP3A4CYP2D6 | |
| SCHEMBL89591 | 0.99 | TUBB1 (0.59) | TUBB1ELANESTAT6CYP3A4CYP2D6 | |
| SCHEMBL14592398 | 0.99 | TUBB1 (0.59) | TUBB1ELANESTAT6CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2374454-A1 | Hemiasterlin derivatives and uses thereof in the treatment of cancer | Eisai R&D Management Co., Ltd. (JP) | 2011-10-12 | — | — | EP | disclosed |