Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 13/20 | 0.63 |
| ▸ | JAK3 | P52333 | 3/20 | 0.59 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | JAK1 | P23458 | 1/20 | 0.59 |
| ▸ | TYK2 | P29597 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2474883 | 0.91 | JAK3 (0.72) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL2481423 | 0.85 | JAK3 (0.64) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL2481521 | 0.83 | JAK3 (0.68) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL2479634 | 0.83 | JAK3 (0.60) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL12301574 | 0.83 | JAK3 (0.73) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL12206772 | 0.83 | JAK3 (0.73) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL2485957 | 0.83 | JAK3 (0.62) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL2474595 | 0.83 | STAT6 (0.60) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL2481110 | 0.83 | STAT6 (0.61) | STAT6JAK3IRAK4JAK2JAK1 | |
| SCHEMBL2477658 | 0.82 | STAT6 (0.59) | STAT6JAK3IRAK4JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380877-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | Kowa Company, Ltd. (JP) | 2011-10-26 | — | — | EP | disclosed |