Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | RPS6KA2 | Q15349 | 3/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1038450 | 0.86 | KDR (0.48) | KDRAURKAAURKBMEN1KMT2A | |
| SCHEMBL1039755 | 0.81 | MEN1 (0.50) | KDRAURKAAURKBMEN1KMT2A | |
| SCHEMBL1222450 | 0.80 | AURKA (0.51) | KDRAURKAAURKBMEN1KMT2A | |
| SCHEMBL12882101 | 0.71 | SYK (0.61) | KDRAURKAAURKBFLT3PTK2 | |
| SCHEMBL29436275 | 0.71 | KDR (0.44) | KDRAURKAAURKBMEN1KMT2A | |
| Calcium SCHEMBL29436268 | 0.70 | KDR (0.43) | KDRAURKAAURKBMEN1KMT2A | |
| SCHEMBL13955883 | 0.69 | IGF1R (0.59) | KDRAURKAAURKBPOLBFLT3 | |
| SCHEMBL4473977 | 0.68 | KDR (0.70) | KDRAURKAAURKBPTK2PLK1 | |
| SCHEMBL29430427 | 0.68 | KDR (0.70) | KDRAURKAAURKBPTK2PLK1 | |
| SCHEMBL5741810 | 0.67 | ZAP70 (0.65) | KDRAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028405-A1 | SULFAMIDES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2011-02-03 | — | — | US | disclosed |
| EP-2234986-A2 | SULFAMIDES AS ZAP-70 INHIBITORS | Cellzome Limited (GB) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009080638-A2 | SULFAMIDES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028405-A1 | SULFAMIDES AS ZAP-70 INHIBITORS | ZAP70, SYK, LCK | KDR 4181/4885AURKA 3725/4885AURKB 3812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.