Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Atomoxetine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 9/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 14/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.97 |
| ▸ | TSHR | P16473 | 3/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.97 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.97 |
| ▸ | HTR2A | P28223 | 2/20 | 0.97 |
| ▸ | HTR2C | P28335 | 2/20 | 0.97 |
| ▸ | HRH1 | P35367 | 2/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.97 |
| ▸ | DRD3 | P35462 | 2/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.97 |
| ▸ | HTR2B | P41595 | 2/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.97 |
| ▸ | KLF10 | Q13118 | 2/20 | 0.97 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Atomoxetine SCHEMBL2206798 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4CYP1A2CYP3A4CYP2D6 | |
| Atomoxetine SCHEMBL649168 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4CYP1A2CYP3A4CYP2D6 | |
| Atomoxetine SCHEMBL1560986 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4CYP1A2CYP3A4CYP2D6 | |
| Atomoxetine SCHEMBL29528186 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4CYP1A2CYP3A4CYP2D6 | |
| Atomoxetine SCHEMBL627231 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4CYP1A2CYP3A4CYP2D6 | |
| Atomoxetine SCHEMBL5783906 | 0.98 | SLC6A4 (1.00) | SLC6A2SLC6A4CYP1A2CYP3A4CYP2D6 | |
| Atomoxetine SCHEMBL29440242 | 0.98 | SLC6A4 (1.00) | SLC6A2SLC6A4CYP1A2CYP3A4CYP2D6 | |
| Atomoxetine SCHEMBL341802 | 0.98 | SLC6A4 (1.00) | SLC6A2SLC6A4CYP1A2CYP3A4CYP2D6 | |
| Atomoxetine SCHEMBL12047445 | 0.98 | SLC6A4 (1.00) | SLC6A2SLC6A4CYP1A2CYP3A4CYP2D6 | |
| Atomoxetine SCHEMBL2209541 | 0.98 | SLC6A4 (1.00) | SLC6A2SLC6A4CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7080 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-114008013-B | Treatment of CNS disorders with sleep disorders | 哥本哈根大学 | 2026-05-15 | — | — | CN | claimed |
| US-20260034151-A1 | TREATMENT OF FRAGILE X SYNDROME AND AUTISM SPECTRUM DISORDER WITH CANNABIDIOL | HARMONY BIOSCIENCES MANAGEMENT, INC. (US) | 2026-02-05 | — | — | US | claimed |
| US-12508315-B2 | Use of vitamin E TPGS as a taste masking agent for bitter drugs | HYLORIS DEVELOPMENTS SA (BE) | 2025-12-30 | — | — | US | claimed |
| US-12491157-B1 | Atomoxetine hydrochloride oral suspension and use thereof | OWP Pharmaceuticals, Inc. | 2025-12-09 | — | — | US | claimed |
| EP-4654949-A1 | USE OF VITAMIN E TPGS AS A TASTE MASKING AGENT FOR BITTER DRUGS | Hyloris Developments SA (BE) | 2025-12-03 | — | — | EP | claimed |
| US-12478584-B1 | Atomoxetine hydrochloride oral suspension and use thereof | OWP PHARMACEUTICALS INC (US) | 2025-11-25 | — | — | US | claimed |
| US-20250345436-A1 | USE OF VITAMIN E TPGS AS A TASTE MASKING AGENT FOR BITTER DRUGS | HYLORIS DEV SA (BE) | 2025-11-13 | — | — | US | claimed |
| US-20250288539-A1 | TREATMENT OF FRAGILE X SYNDROME AND AUTISM SPECTRUM DISORDER WITH CANNABIDIOL | HARMONY BIOSCIENCES MANAGEMENT, INC. (US) | 2025-09-18 | — | — | US | claimed |
| CN-120142549-A | Method for simultaneously measuring contents of sorbitol, xylitol, sucralose and sodium benzoate | 深圳海王医药科技研究院有限公司 | 2025-06-13 | — | — | CN | claimed |
| WO-1997041878-A1 | TREATMENT OF MOOD DISORDERS WITH A GROWTH HORMONE SECRETAGOGUE | MERCK & CO., INC. (US) | 1997-11-13 | — | — | WO | claimed |
| US-5658590-A | Treatment of attention-deficit/hyperactivity disorder | ELI LILLY AND COMPANY (US) | 1997-08-19 | — | — | US | claimed |
| WO-1996021430-A1 | TREATMENT OF ATTENTION-DEFICIT/HYPERACTIVITY DISORDER | ELI LILLY AND COMPANY (US) | 1996-07-18 | — | — | WO | claimed |
| EP-0721777-A2 | Use of tomoxetine for the treatment of attention deficit/hyperactivity disorder | ELI LILLY AND COMPANY (US) | 1996-07-17 | — | — | EP | claimed |
| EP-0501705-B1 | Use of tomoxetine for the treatment of lower urinary tract disorders | LILLY CO ELI (US) | 1996-05-15 | — | — | EP | claimed |
| US-5441985-A | Treatment of lower urinary tract disorders with selective norepinephrine uptake inhibitors | ELI LILLY AND COMPANY (US) | 1995-08-15 | — | — | US | claimed |
| EP-0501705-A1 | Use of tomoxetine for the treatment of lower urinary tract disorders | ELI LILLY AND COMPANY (US) | 1992-09-02 | — | — | EP | claimed |
| US-4847092-A | GELATIN CAPSULES | ELI LILLY AND COMPANY (US) | 1989-07-11 | — | — | US | claimed |
| EP-0303961-A2 | Novel antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-02-22 | — | — | EP | claimed |
| EP-0222614-A2 | Orally administerable sustained release pharmaceutical formulations | ELI LILLY AND COMPANY (US) | 1987-05-20 | — | — | EP | claimed |