Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 15/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1223057 | 0.93 | DPP4 (0.72) | DPP4CHRM1LMNACHRM2CHRM3 | |
| Trifluoroacetic Acid SCHEMBL1223993 | 0.90 | DPP4 (0.68) | DPP4CHRM1LMNACHRM2CHRM3 | |
| Hydrochloric Acid SCHEMBL1223118 | 0.88 | DPP4 (0.77) | DPP4CHRM1LMNACHRM2CHRM3 | |
| Trifluoroacetic Acid SCHEMBL1223327 | 0.86 | DPP4 (0.68) | DPP4CHRM1LMNACHRM2CHRM3 | |
| Hydrochloric Acid SCHEMBL1222206 | 0.86 | DPP4 (0.81) | DPP4CHRM1LMNACHRM2CHRM3 | |
| Trifluoroacetic Acid SCHEMBL1223486 | 0.86 | DPP4 (0.68) | DPP4CHRM1LMNACHRM2CHRM3 | |
| Hydrochloric Acid SCHEMBL1222196 | 0.85 | DPP4 (0.80) | DPP4CHRM1LMNACHRM2CHRM3 | |
| Trifluoroacetic Acid SCHEMBL1222612 | 0.85 | DPP4 (0.70) | DPP4CHRM1CHRM2CHRM3KCNH2 | |
| Hydrochloric Acid SCHEMBL1223313 | 0.84 | DPP4 (0.79) | DPP4CHRM1LMNACHRM2CHRM3 | |
| Hydrochloric Acid SCHEMBL1223046 | 0.83 | DPP4 (0.77) | DPP4CHRM1LMNACHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888343-B2 | Substituted, bicyclic 8-pyrrolidinoxanthines, and methods for their use as inhibitors of dipeptidyl peptidase | Sanofi-A Ventis Deutschland GmbH (DE) | 2011-02-15 | — | — | US | disclosed |
| US-20070197563-A1 | SUBSTITUTED, BICYCLIC 8-PYRROLIDINOXANTHINES, AND METHODS FOR THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-23 | — | — | US | disclosed |
| EP-1778697-A1 | SUBSTITUTED BICYCLIC 8-PYRROLIDINO-XANTHINES AND USE THEREOF AS INHIBITORS OF THE DIPEPTIDYL PEPTIDASE IV | Sanofi-Aventis Deutschland GmbH (DE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006015699-A1 | SUBSTITUTED BICYCLIC 8-PYRROLIDINO-XANTHINES AND USE THEREOF AS INHIBITORS OF THE DIPEPTIDYL PEPTIDASE IV | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197563-A1 | SUBSTITUTED, BICYCLIC 8-PYRROLIDINOXANTHINES, AND METHODS FOR THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE | DPP8, DPP7, DPP4 | DPP4 3/4885CHRM1 4838/4885LMNA 1392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.