⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15046729 | 0.86 | — | — | |
| SCHEMBL9617831 | 0.73 | — | — | |
| SCHEMBL17795859 | 0.69 | — | — | |
| SCHEMBL171722 | 0.69 | — | — | |
| SCHEMBL351712 | 0.67 | — | — | |
| SCHEMBL20431129 | 0.67 | — | — | |
| SCHEMBL17472260 | 0.67 | — | — | |
| SCHEMBL15326932 | 0.65 | — | — | |
| SCHEMBL22173859 | 0.65 | — | — | |
| SCHEMBL232122 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034945-B2 | 4-phenyl-5-OXO-1,4,5,6,7,8-hexahydroquinoline derivatives as medicaments for the treatment of infertility | N.V. ORGANON (NL) | 2011-10-11 | — | — | US | disclosed |
| US-8022218-B2 | Hypogonadism; N-{3-[2-Bromo-4-(3-cyano-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinolin-4-yl)-6-ethoxy-phenoxymethyl]-phenyl}-3,4,5-trimethoxy-benzamide; low molecular weight hormone mimetics; selective Follicle Stimulating Hormone receptor agonists | N.V. ORGANON (NL) | 2011-09-20 | — | — | US | disclosed |
| US-8017782-B2 | hypogonadism and male infertility; ovulation induction | N.V. ORGANON (NL) | 2011-09-13 | — | — | US | disclosed |
| US-7994189-B2 | Dihydropyridine derivatives | N.V. ORGANON (NL) | 2011-08-09 | — | — | US | disclosed |
| US-20090215773-A1 | DIHYDROPYRIDINE DERIVATIVES | N.V.ORGANON (NL) | 2009-08-27 | — | — | US | disclosed |
| US-20080300270-A1 | 4-Phenyl-5-Oxo-1,4,5,6,7,8,- Hexahydroquinoline Derivatives as Medicaments for the Treatment of Infertility | MERCK SHARP & DOHME B.V. (NL) | 2008-12-04 | — | — | US | disclosed |
| US-20080275042-A1 | 4-Phenyl-5-Oxo-1,4,5,6,7,8-Hexahydroquinoline Derivatives for the Treatment of Infertility | N.V. ORGANON (NL) | 2008-11-06 | — | — | US | disclosed |
| US-20080262033-A1 | 4-Phenyl-5-Oxo-1,4,5,6,7,8- Hexahydroquinoline Derivatives as Medicaments for the Treatment of Infertility | MERCK SHARP & DOHME B.V. (NL) | 2008-10-23 | — | — | US | disclosed |