Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 2/20 | 0.55 |
| ▸ | ENTPD5 | O75356 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 3/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12234043 | 1.00 | PIK3CB (0.55) | PIK3CBENTPD5CYP19A1TRPV1ALDH1A1 | |
| SCHEMBL23995072 | 1.00 | PIK3CB (0.55) | PIK3CBENTPD5CYP19A1TRPV1ALDH1A1 | |
| SCHEMBL12234050 | 1.00 | PIK3CB (0.55) | PIK3CBENTPD5CYP19A1TRPV1ALDH1A1 | |
| SCHEMBL12234049 | 1.00 | PIK3CB (0.55) | PIK3CBENTPD5CYP19A1TRPV1ALDH1A1 | |
| SCHEMBL12234040 | 0.88 | ENTPD5 (0.53) | PIK3CBENTPD5CYP19A1TRPV1ALDH1A1 | |
| SCHEMBL12234310 | 0.88 | ENTPD5 (0.53) | PIK3CBENTPD5CYP19A1TRPV1ALDH1A1 | |
| SCHEMBL14373570 | 0.88 | PIK3CB (0.54) | PIK3CBENTPD5CYP19A1TRPV1ALDH1A1 | |
| SCHEMBL12234302 | 0.88 | ENTPD5 (0.53) | PIK3CBENTPD5CYP19A1TRPV1ALDH1A1 | |
| SCHEMBL14373501 | 0.88 | PIK3CB (0.54) | PIK3CBENTPD5CYP19A1TRPV1ALDH1A1 | |
| SCHEMBL12234029 | 0.88 | ENTPD5 (0.53) | PIK3CBENTPD5CYP19A1TRPV1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263539-A1 | SHIP 1 MODULATOR COMPOUNDS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2011-10-27 | — | — | US | disclosed |
| US-20110263539-A1 | SHIP 1 MODULATOR COMPOUNDS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2011-10-27 | — | — | US | disclosed |
| WO-2007147251-A1 | SHIP 1 MODULATOR COMPOUNDS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263539-A1 | SHIP 1 MODULATOR COMPOUNDS | PPM1F, PPM1D, PPP1R1B | PIK3CB 87/4885ENTPD5 470/4885CYP19A1 2683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.