Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12235135 | 1.00 | GRM5 (0.71) | GRM5PDE4B | |
| SCHEMBL12234324 | 1.00 | GRM5 (0.71) | GRM5PDE4B | |
| SCHEMBL12285037 | 0.85 | GRM5 (0.52) | GRM5PDE4B | |
| SCHEMBL12235936 | 0.83 | GRM5 (0.74) | GRM5 | |
| SCHEMBL12235257 | 0.83 | GRM5 (0.74) | GRM5 | |
| SCHEMBL12235256 | 0.83 | GRM5 (0.74) | GRM5 | |
| SCHEMBL2518261 | 0.83 | GRM5 (1.00) | GRM5 | |
| SCHEMBL12211863 | 0.83 | GRM5 (1.00) | GRM5 | |
| SCHEMBL2518267 | 0.83 | GRM5 (1.00) | GRM5 | |
| SCHEMBL12235168 | 0.79 | GRM5 (0.72) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011128279-A1 | ARYLETHYNYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-20 | — | — | WO | disclosed |
| US-20110251169-A1 | Arylethynyl derivatives | HOFFMANN-LA ROCHE, INC. | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251169-A1 | Arylethynyl derivatives | GRM5, GRM1, GRM3 | GRM5 1/4885PDE4B 1766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.