Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 19/20 | 0.69 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12235217 | 0.86 | GRM5 (0.69) | GRM5 | |
| SCHEMBL12236464 | 0.86 | GRM5 (0.68) | GRM5 | |
| SCHEMBL12235922 | 0.84 | GRM5 (0.71) | GRM5 | |
| SCHEMBL12234477 | 0.82 | GRM5 (0.71) | GRM5 | |
| SCHEMBL2520847 | 0.82 | GRM5 (1.00) | GRM5 | |
| SCHEMBL12234289 | 0.81 | GRM5 (0.69) | GRM5CTSDBACE1 | |
| SCHEMBL12234275 | 0.80 | GRM5 (0.67) | GRM5 | |
| SCHEMBL12235375 | 0.79 | GRM5 (0.72) | GRM5 | |
| SCHEMBL12235865 | 0.78 | GRM5 (0.69) | GRM5 | |
| SCHEMBL12234514 | 0.78 | GRM5 (0.65) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110251169-A1 | Arylethynyl derivatives | HOFFMANN-LA ROCHE, INC. | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251169-A1 | Arylethynyl derivatives | GRM5, GRM1, GRM3 | GRM5 1/4885CTSD 4614/4885BACE1 3931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.