⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18254276 | 1.00 | — | — | |
| SCHEMBL18254275 | 1.00 | — | — | |
| SCHEMBL4413337 | 0.78 | TP53 (0.44) | — | |
| SCHEMBL1620570 | 0.75 | TP53 (0.42) | — | |
| SCHEMBL2182690 | 0.75 | — | — | |
| SCHEMBL792711 | 0.75 | — | — | |
| SCHEMBL23829601 | 0.73 | — | — | |
| SCHEMBL9626465 | 0.73 | — | — | |
| SCHEMBL5840601 | 0.73 | — | — | |
| SCHEMBL18254517 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204363-A1 | SUBSTITUTED PYRIMIDINES AS INHIBITORS OF HIF PROLYL HYDROXYLASE | Merck Sharp & Dohme Corp. (US) | 2017-08-16 | — | — | EP | claimed |
| WO-2016057762-A1 | SUBSTITUTED PYRIMIDINES AS INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP (US) | 2016-04-14 | — | — | WO | claimed |
| US-20260103459-A1 | SUBSTITUTED AZACYLES AS TRPM8 MODULATORS | GIVAUDAN SA (CH) | 2026-04-16 | — | — | US | disclosed |
| US-12528801-B2 | Substituted azacyles as TRPM8 modulators | GIVAUDAN SA (CH) | 2026-01-20 | — | — | US | disclosed |
| CN-119823007-A | Micro-channel continuous flow preparation method for oxidizing thioether compounds into sulfones compounds | 江苏倍合德医药科技有限公司 | 2025-04-15 | — | — | CN | disclosed |
| CN-114555594-B | Substituted azacycles as TRMP modulators | 奇华顿股份有限公司 | 2025-03-18 | — | — | CN | disclosed |
| WO-2024196936-A2 | LOCALIZED HIGH CONCENTRATION ELECTROLYTE AND LITHIUM-ION BATTERY COMPRISING THE SAME | SILA NANOTECHNOLOGIES, INC. (US) | 2024-09-26 | — | — | WO | disclosed |
| US-20240132487-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | GIVAUDAN SA (CH) | 2024-04-25 | — | — | US | disclosed |
| US-20240109846-A1 | PROCESSES RELATED TO FORMATION OF N-(3-CHLORO-1-(PYRIDIN-3-YL)-1H-PYRAZOL-4-YL)-2-(METHYLSULFONYL)PROPANAMIDE | CORTEVA AGRISCIENCE LLC (US) | 2024-04-04 | — | — | US | disclosed |
| EP-4281440-A1 | PROCESSES RELATED TO FORMATION OF N-(3-CHLORO-1-(PYRIDIN-3-YL)-1H-PYRAZOL-4-YL)-2-(METHYLSULFONYL)PROPANAMIDE | Corteva Agriscience LLC (US) | 2023-11-29 | — | — | EP | disclosed |
| EP-3998260-B1 | SGC STIMULATORS | CYCLERION THERAPEUTICS INC (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-0861249-A1 | SUBSTITUTED SULFONYLALKANOYLAMINO HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-09-02 | — | — | EP | disclosed |
| CN-1183767-A | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors | SEARLE & CO (US) | 1998-06-03 | — | — | CN | disclosed |
| US-5760064-A | RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE (US) | 1998-06-02 | — | — | US | disclosed |
| EP-0813519-A1 | SULFONYLALKANOYLAMINO HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-12-29 | — | — | EP | disclosed |
| WO-1997018205-A1 | SUBSTITUTED SULFONYLALKANOYLAMINO HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-05-22 | — | — | WO | disclosed |
| EP-0666843-A1 | SULFONYLALKANOYLAMINO HYDROXYETHYLAMINO SULFAMIC ACIDS USEFUL AS RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1995-08-16 | — | — | EP | disclosed |
| EP-0656888-A1 | SULFONYLALKANOYLAMINO HYDROXYETHYLAMINO SULFONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1995-06-14 | — | — | EP | disclosed |
| WO-1994004493-A1 | SULFONYLALKANOYLAMINO HYDROXYETHYLAMINO SULFONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1994-03-03 | — | — | WO | disclosed |
| EP-0321784-A2 | Formazane dyes containing heavy metals, process for their preparation and their use in dyeing and printing fibrous materials | BAYER AG (DE) | 1989-06-28 | — | — | EP | disclosed |