Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 3/20 | 0.59 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.59 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.59 |
| ▸ | GRM5 | P41594 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | IL2 | P60568 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | IDE | P14735 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12155639 | 0.91 | STIM1 (0.60) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL16572267 | 0.89 | STIM1 (0.57) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL17244771 | 0.87 | STIM1 (0.57) | STIM1ORAI1ORAI2GRM5NPC1 | |
| SCHEMBL1702182 | 0.84 | STIM1 (0.77) | STIM1ORAI1ORAI2IL2KMT2A | |
| SCHEMBL12156041 | 0.83 | STIM1 (0.61) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL18081993 | 0.83 | STIM1 (0.84) | STIM1ORAI1ORAI2IL2L3MBTL1 | |
| SCHEMBL1701611 | 0.82 | STIM1 (0.65) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL16018246 | 0.81 | STIM1 (0.56) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL1701748 | 0.81 | STIM1 (0.64) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL12156046 | 0.80 | STIM1 (0.57) | STIM1ORAI1ORAI2IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263612-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263612-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | STIM1 17/4885ORAI1 1/4885ORAI2 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.