SCHEMBL12250992

SCHEMBL12250992

COC(=O)c1ccc(-c2nc(-c3ccccc3)nc(-c3ccc(C#N)cc3O)n2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.56
PLAU P00749 2/20 0.47
MAPT P10636 3/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
POLB P06746 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
ABCG2 Q9UNQ0 5/20 0.44
ABCC1 P33527 2/20 0.44
PDE5A O76074 1/20 0.44
ABCB1 P08183 4/20 0.43
PTGS2 P35354 1/20 0.43
ALDH1A1 P00352 2/20 0.42
ALDH1A3 P47895 2/20 0.42
TSHR P16473 2/20 0.42
NPC1 O15118 1/20 0.42
CRHBP P24387 1/20 0.42
RAB9A P51151 1/20 0.42
CRHR2 Q13324 1/20 0.42
ALDH1A2 O94788 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9608436 0.94 MAPT (0.51) EGFRPLAUMAPTMEN1KMT2A
SCHEMBL12228452 0.86 EGFR (0.66) EGFRMAPTMEN1KMT2APOLB
SCHEMBL12755045 0.86 MAPT (0.47) EGFRPLAUMAPTMEN1KMT2A
SCHEMBL9608538 0.85 MEN1 (0.50) EGFRPLAUMAPTMEN1KMT2A
SCHEMBL12228432 0.85 NPC1 (0.46) EGFRPLAUMAPTPOLBNPC1
SCHEMBL12228445 0.83 EGFR (0.61) EGFRMAPTMEN1KMT2APOLB
SCHEMBL12228453 0.83 EGFR (0.61) EGFRMAPTMEN1KMT2APOLB
SCHEMBL12228440 0.82 EGFR (0.59) EGFRMAPTMEN1KMT2APOLB
SCHEMBL12228448 0.82 EGFR (0.60) EGFRPLAUMAPTMEN1KMT2A
SCHEMBL12228455 0.82 EGFR (0.60) EGFRPLAUMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8044123-B2 Ultraviolet absorber composition and resin composition FUJIFILM CORPORATION (JP) 2011-10-25 US disclosed
US-20110077330-A1 POLYCARBONATE RESIN COMPOSITION CONTAINING TRIAZINE COMPOUND AND MOLDED ARTICLE USING THE SAME FUJIFILM CORPORATION (JP) 2011-03-31 US disclosed
US-20100324181-A1 ULTRAVIOLET ABSORBER COMPOSITION AND RESIN COMPOSITION FUJIFILM CORPORATION (JP) 2010-12-23 US disclosed
US-20100311877-A1 NOVEL TRIAZINE DERIVATIVE, ULTRAVIOLET ABSORBER, AND RESIN COMPOSITION FUJIFILM CORPORATION (JP) 2010-12-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100311877-A1 NOVEL TRIAZINE DERIVATIVE, ULTRAVIOLET ABSORBER, AND RESIN COMPOSITION AVPR1B, H1-0, H1-2 EGFR 4552/4885PLAU 3393/4885MAPT 2637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.