Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.65 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903879 | 1.00 | NR1H2 (0.65) | NR1H2JAK1JAK2GPR119NAMPT | |
| SCHEMBL371676 | 1.00 | NR1H2 (0.65) | NR1H2JAK1JAK2GPR119NAMPT | |
| SCHEMBL15755272 | 0.96 | NR1H2 (0.60) | NR1H2JAK1JAK2GPR119NAMPT | |
| SCHEMBL10093467 | 0.89 | NR1H2 (0.55) | NR1H2JAK1JAK2GPR119NAMPT | |
| SCHEMBL343549 | 0.89 | NR1H2 (0.55) | NR1H2JAK1JAK2GPR119NAMPT | |
| SCHEMBL343551 | 0.89 | NR1H2 (0.55) | NR1H2JAK1JAK2GPR119NAMPT | |
| SCHEMBL343550 | 0.89 | NR1H2 (0.55) | NR1H2JAK1JAK2GPR119NAMPT | |
| SCHEMBL445759 | 0.88 | NR1H2 (0.51) | NR1H2GPR119NAMPTUSP2SMN1; SMN2 | |
| SCHEMBL29674207 | 0.86 | NR1H2 (0.54) | NR1H2JAK1JAK2GPR119NAMPT | |
| SCHEMBL30164990 | 0.83 | NR1H2 (0.57) | NR1H2GPR119NAMPTUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280003-A2 | Process for preparing receptor-type kinase modulators | Symphony Evolution, Inc. (US) | 2011-02-02 | — | — | EP | claimed |