Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL415683 | 0.89 | ERN1 (0.57) | ERN1ALDH1A1SMN1; SMN2ACHEPRKDC | |
| SCHEMBL27986280 | 0.82 | ERN1 (0.38) | ERN1ALDH1A1SMN1; SMN2ACHEABCB1 | |
| SCHEMBL4099200 | 0.82 | ERN1 (0.65) | ERN1ALDH1A1PRKDCTSHRKDM4E | |
| SCHEMBL27181737 | 0.80 | ERN1 (0.44) | ERN1ALDH1A1SMN1; SMN2PRKDCTSHR | |
| SCHEMBL9279963 | 0.80 | ERN1 (0.51) | ERN1ALDH1A1SMN1; SMN2PRKDCTSHR | |
| SCHEMBL5358719 | 0.80 | ERN1 (0.68) | ERN1ALDH1A1SMN1; SMN2ACHEPRKDC | |
| SCHEMBL16675873 | 0.80 | ERN1 (0.51) | ERN1ALDH1A1SMN1; SMN2PRKDCTSHR | |
| SCHEMBL12581710 | 0.80 | PRKDC (0.53) | ERN1ALDH1A1SMN1; SMN2ACHEPRKDC | |
| SCHEMBL2027384 | 0.80 | ERN1 (0.58) | ERN1ALDH1A1SMN1; SMN2PRKDCTSHR | |
| SCHEMBL4000526 | 0.80 | ERN1 (0.38) | ERN1ALDH1A1SMN1; SMN2ACHEABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9676728-B2 | 2-benzyl-benzimidazole complement factor B inhibitors and uses thereof | NOVARTIS AG (CH) | 2017-06-13 | — | — | US | disclosed |
| US-9676728-B2 | 2-benzyl-benzimidazole complement factor B inhibitors and uses thereof | NOVARTIS AG (CH) | 2017-06-13 | — | — | US | disclosed |
| US-9676728-B2 | 2-benzyl-benzimidazole complement factor B inhibitors and uses thereof | NOVARTIS AG (CH) | 2017-06-13 | — | — | US | disclosed |
| EP-2427425-B1 | TETRACYCLINE COMPOUNDS | TETRAPHASE PHARMACEUTICALS INC (US) | 2017-03-08 | — | — | EP | disclosed |
| EP-2334175-B1 | PHENYL-SUBSTITUTED BICYCLOOCTANE 1,3 DIONE DERIVATIVES | BAYER IP GMBH (DE) | 2017-03-01 | — | — | EP | disclosed |
| EP-3089963-A1 | 2-BENZYL-BENZIMIDAZOLE COMPLEMENT FACTOR B INHIBITORS AND USES THEREOF | Novartis AG (CH) | 2016-11-09 | — | — | EP | disclosed |
| US-20160311779-A1 | 2-BENZYL-BENZIMIDAZOLE COMPLEMENT FACTOR B INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2016-10-27 | — | — | US | disclosed |
| US-20160311779-A1 | 2-BENZYL-BENZIMIDAZOLE COMPLEMENT FACTOR B INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2016-10-27 | — | — | US | disclosed |
| US-20160311779-A1 | 2-BENZYL-BENZIMIDAZOLE COMPLEMENT FACTOR B INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2016-10-27 | — | — | US | disclosed |
| WO-2015066241-A1 | 2-BENZYL-BENZIMIDAZOLE COMPLEMENT FACTOR B INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2015-05-07 | — | — | WO | disclosed |
| US-8367873-B2 | Phenyl-substituted bicyclooctane-1,3-dione derivatives | BAYER CROPSCIENCE AG (DE) | 2013-02-05 | — | — | US | disclosed |
| US-8343944-B2 | Trisubstituted boron-containing molecules | ANACOR PHARMACEUTICALS, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| EP-2334175-A2 | PHENYL-SUBSTITUTED BICYCLOOCTANE-1,3-DIONE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2011-06-22 | — | — | EP | disclosed |
| US-20110136763-A1 | TRISUBSTITUTED BORON-CONTAINING MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2011-06-09 | — | — | US | disclosed |
| US-20110039701-A1 | Phenyl-substituted Bicyclooctane-1,3-dione Derivatives | BAYER CROPSCIENCE AG (DE) | 2011-02-17 | — | — | US | disclosed |
| WO-2010040460-A2 | PHENYL-SUBSTITUTED BICYCLOOCTANE-1,3-DIONE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2010-04-15 | — | — | WO | disclosed |
| US-5457239-A | Process for formylation of aromatic compounds | UNION CAMP CORPORATION (US) | 1995-10-10 | — | — | US | disclosed |
| US-4806141-A | 1-OXY-2-OXIMO-3-OXO-5-PHENYL CYCLOMEXENE | ICI AUSTRALIA LIMITED (AU) | 1989-02-21 | — | — | US | disclosed |
| EP-0085530-B1 | CYCLOHEXANE DIONE DERIVATIVES, THEIR USE AS HERBICIDES, HERBICIDAL COMPOSITIONS CONTAINING THEM, AND METHODS OF PREPARING THEM | ICI AUSTRALIA LIMITED (AU) | 1987-07-01 | — | — | EP | disclosed |
| EP-0085530-A2 | Cyclohexane dione derivatives, their use as herbicides, herbicidal compositions containing them, and methods of preparing them | ICI AUSTRALIA LIMITED (AU) | 1983-08-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039701-A1 | Phenyl-substituted Bicyclooctane-1,3-dione Derivatives | DDT, PIP5K1B, PIP5K1C | ERN1 2591/4885ALDH1A1 2618/4885SMN1; SMN2 4217/4885 |
| US-20110136763-A1 | TRISUBSTITUTED BORON-CONTAINING MOLECULES | BCL6B, BCL6, BLK | ERN1 3820/4885ALDH1A1 3788/4885SMN1; SMN2 3630/4885 |
| US-20160311779-A1 | 2-BENZYL-BENZIMIDAZOLE COMPLEMENT FACTOR B INHIBITORS AND USES THEREOF | CFB, F13B, CFH | ERN1 3086/4885ALDH1A1 1604/4885SMN1; SMN2 3508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.