Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.79 |
| ▸ | MET | P08581 | 1/20 | 0.79 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.79 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.79 |
| ▸ | AXL | P30530 | 1/20 | 0.79 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | YES1 | P07947 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1225592 | 1.00 | FGFR1 (0.79) | FGFR1METFGFR2FGFR3AXL | |
| Hydrochloric Acid SCHEMBL259820 | 0.99 | FGFR1 (0.78) | FGFR1METFGFR2FGFR3AXL | |
| Hydrochloric Acid SCHEMBL259819 | 0.99 | FGFR1 (0.78) | FGFR1METFGFR2FGFR3AXL | |
| SCHEMBL261052 | 0.89 | FGFR1 (0.75) | FGFR1METFGFR2FGFR3AXL | |
| SCHEMBL261053 | 0.89 | FGFR1 (0.75) | FGFR1METFGFR2FGFR3AXL | |
| SCHEMBL29360864 | 0.89 | FGFR1 (1.00) | FGFR1METFGFR2FGFR3AXL | |
| SCHEMBL259822 | 0.89 | FGFR1 (1.00) | FGFR1METFGFR2FGFR3AXL | |
| Hydrochloric Acid SCHEMBL260332 | 0.89 | FGFR1 (0.73) | FGFR1METFGFR2FGFR3AXL | |
| SCHEMBL259823 | 0.89 | FGFR1 (1.00) | FGFR1METFGFR2FGFR3AXL | |
| SCHEMBL20412333 | 0.89 | FGFR1 (1.00) | FGFR1METFGFR2FGFR3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2281822-B1 | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2013-01-16 | — | — | EP | disclosed |
| EP-2281822-A1 | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2011-02-09 | — | — | EP | disclosed |