Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 11/20 | 0.58 |
| ▸ | NR0B2 | Q15466 | 4/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12257902 | 0.82 | PTPN11 (0.58) | PTPN11NR0B2RXRANR4A2KDM4E | |
| SCHEMBL12257892 | 0.73 | PTPN11 (1.00) | PTPN11NR0B2RXRANR4A2KDM4E | |
| SCHEMBL3290498 | 0.72 | PTPN11 (0.60) | PTPN11NR0B2KDM4EHSD17B10MEN1 | |
| SCHEMBL12309639 | 0.71 | PTPN11 (0.77) | PTPN11NR0B2RXRANR4A2KDM4E | |
| SCHEMBL1914213 | 0.71 | PTPN11 (1.00) | PTPN11NR0B2HDAC3HDAC4HDAC1 | |
| SCHEMBL29604865 | 0.71 | PTPN11 (1.00) | PTPN11NR0B2HDAC3HDAC4HDAC1 | |
| SCHEMBL1914215 | 0.71 | PTPN11 (1.00) | PTPN11NR0B2HDAC3HDAC4HDAC1 | |
| SCHEMBL12257895 | 0.69 | PTPN11 (1.00) | PTPN11NR0B2RXRANR4A2KDM4E | |
| SCHEMBL6022866 | 0.69 | KDM4E (0.70) | PTPN11NR0B2KDM4EHSD17B10MEN1 | |
| SCHEMBL6022871 | 0.69 | KDM4E (0.70) | PTPN11NR0B2KDM4EHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42700-E1 | Induction of apoptosis in cancer cells | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-13 | — | — | US | disclosed |
| US-RE42700-E1 | Induction of apoptosis in cancer cells | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-13 | — | — | US | disclosed |