Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | ACACA | Q13085 | 2/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | GRK6 | P43250 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12264148 | 0.84 | PDE4B (0.42) | ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL12265549 | 0.83 | GRK6 (0.39) | MAPTALDH1A1POLBKMT2AKDM4E | |
| SCHEMBL2508093 | 0.81 | MAPT (0.38) | MAPTALDH1A1TSHREGFRPOLB | |
| SCHEMBL2510327 | 0.81 | MAPT (0.38) | MAPTALDH1A1TSHREGFRPOLB | |
| SCHEMBL2505608 | 0.70 | CNR1 (0.45) | MAPTALDH1A1CNR2KDM4E | |
| SCHEMBL2507261 | 0.69 | PIK3CD (0.59) | — | |
| SCHEMBL2508692 | 0.68 | TP53 (0.39) | ALDH1A1CNR2EGFRKDM4EOPRM1 | |
| SCHEMBL2505347 | 0.68 | TP53 (0.39) | ALDH1A1CNR2EGFRKDM4EOPRM1 | |
| SCHEMBL2505074 | 0.68 | PIK3CD (0.38) | CNR2EGFROPRM1OPRD1GRK6 | |
| SCHEMBL2505077 | 0.68 | PIK3CD (0.38) | CNR2EGFROPRM1OPRD1GRK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123751-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | WO | disclosed |