⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12009801 | 0.79 | — | — | |
| SCHEMBL12604242 | 0.78 | TSHR (0.32) | — | |
| SCHEMBL15385318 | 0.77 | — | — | |
| SCHEMBL15385403 | 0.77 | — | — | |
| SCHEMBL15385396 | 0.77 | — | — | |
| SCHEMBL16418203 | 0.74 | CYP3A4 (0.34) | — | |
| SCHEMBL12825900 | 0.74 | CYP3A4 (0.34) | — | |
| SCHEMBL16865743 | 0.73 | — | — | |
| SCHEMBL15150455 | 0.73 | — | — | |
| SCHEMBL12277446 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130211103-A1 | INTERMEDIATES AND METHODS FOR MAKING ZEARALENONE MACROLIDE ANALOGS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-08-15 | — | — | US | disclosed |
| US-8507696-B2 | Intermediates in the synthesis zearalenone macrolide analogs | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-08-13 | — | — | US | disclosed |
| US-8350059-B2 | Intermediates and methods for making zearalenone macrolide analogs | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-01-08 | — | — | US | disclosed |
| US-20110237805-A1 | INTERMEDIATES AND METHODS FOR MAKING ZEARALENONE MACROLIDE ANALOGS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-09-29 | — | — | US | disclosed |
| US-20110046398-A1 | INTERMEDIATES IN THE SYNTHESIS ZEARALENONE MACROLIDE ANALOGS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-02-24 | — | — | US | disclosed |