Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.64 |
| ▸ | JAK3 | P52333 | 7/20 | 0.64 |
| ▸ | JAK2 | O60674 | 6/20 | 0.64 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.64 |
| ▸ | BRD2 | P25440 | 1/20 | 0.64 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.64 |
| ▸ | JAK1 | P23458 | 6/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.63 |
| ▸ | TYK2 | P29597 | 3/20 | 0.63 |
| ▸ | RET | P07949 | 2/20 | 0.63 |
| ▸ | FLT3 | P36888 | 2/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | SRC | P12931 | 5/20 | 0.62 |
| ▸ | AXL | P30530 | 3/20 | 0.62 |
| ▸ | KDR | P35968 | 3/20 | 0.62 |
| ▸ | MERTK | Q12866 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 2/20 | 0.62 |
| ▸ | TEK | Q02763 | 2/20 | 0.62 |
| ▸ | BTK | Q06187 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL270087 | 0.90 | BRD4 (0.73) | BRD4JAK3JAK2BRDTBRD2 | |
| Hydrochloric Acid SCHEMBL263793 | 0.89 | BRD4 (0.72) | BRD4JAK3JAK2BRDTBRD2 | |
| SCHEMBL270718 | 0.89 | BRD4 (0.75) | BRD4JAK3JAK2BRDTBRD2 | |
| Hydrochloric Acid SCHEMBL264170 | 0.88 | BRD4 (0.73) | BRD4JAK3JAK2BRDTBRD2 | |
| SCHEMBL269991 | 0.86 | JAK1 (0.75) | BRD4JAK3JAK2BRDTBRD2 | |
| SCHEMBL18226520 | 0.85 | BRD4 (0.80) | BRD4JAK3JAK2BRDTBRD2 | |
| Hydrochloric Acid SCHEMBL265421 | 0.85 | JAK1 (0.74) | BRD4JAK3JAK2BRDTBRD2 | |
| SCHEMBL271058 | 0.84 | BRD4 (0.74) | BRD4JAK3JAK2BRDTBRD2 | |
| SCHEMBL270660 | 0.83 | JAK3 (0.72) | BRD4JAK3JAK2BRDTBRD2 | |
| SCHEMBL18225176 | 0.83 | BRD4 (0.83) | BRD4JAK3JAK2BRDTBRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212077-A1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | TARGEGEN, INC. (US) | 2011-09-01 | — | — | US | disclosed |
| US-20110212077-A1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | TARGEGEN, INC. (US) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212077-A1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | JAK2, TYK2, JAK3 | BRD4 142/4885JAK3 3/4885JAK2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.