Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 12/20 | 0.45 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.42 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12280717 | 0.89 | NPC1 (0.43) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL12280281 | 0.86 | IL2 (0.44) | IL2STIM1ORAI1MEN1KMT2A | |
| SCHEMBL12241307 | 0.86 | IL2 (0.50) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL12241306 | 0.85 | IL2 (0.45) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL12241322 | 0.84 | IL2 (0.50) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL12280274 | 0.83 | NPC1 (0.43) | IL2MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL12156185 | 0.83 | IL2 (0.45) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL16572614 | 0.77 | IL2 (0.47) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL16572613 | 0.76 | IL2 (0.42) | IL2STIM1ORAI1ORAI2HCRTR1 | |
| SCHEMBL12241312 | 0.75 | SMN1; SMN2 (0.50) | IL2MEN1KMT2AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263612-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263612-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | IL2 3716/4885STIM1 17/4885ORAI1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.