Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 6/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29306578 | 0.84 | EPHX1 (0.58) | MEN1KMT2AEPHX1ALDH1A1POLB | |
| SCHEMBL11922844 | 0.83 | TDP1 (0.58) | TDP1MEN1KMT2APTGS1KCNH2 | |
| SCHEMBL12565693 | 0.83 | CNR1 (0.46) | TDP1MEN1KMT2APTGS1KCNH2 | |
| SCHEMBL15001321 | 0.82 | TDP1 (0.49) | TDP1MEN1KMT2APTGS1KCNH2 | |
| SCHEMBL618269 | 0.82 | EPHX1 (0.50) | EPHX1NAAAACHECNR1 | |
| SCHEMBL5542570 | 0.81 | TDP1 (0.55) | TDP1MEN1KMT2APTGS1KCNH2 | |
| SCHEMBL2746780 | 0.80 | TDP1 (0.55) | TDP1MEN1KMT2APTGS1KCNH2 | |
| SCHEMBL2746057 | 0.80 | TDP1 (0.55) | TDP1MEN1KMT2APTGS1KCNH2 | |
| SCHEMBL21976540 | 0.79 | PTGS1 (0.47) | TDP1MEN1KMT2APTGS1KCNH2 | |
| SCHEMBL17447509 | 0.78 | PTGS1 (0.46) | TDP1MEN1KMT2APTGS1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011126974-A1 | NOVEL SINGLE CHEMICAL ENTITIES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES | MERCK SHARP & DOHME CORP. (US) | 2011-10-13 | — | — | WO | disclosed |