Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL1229954 | 0.94 | KDM4E (0.37) | KDM4EHDAC4HDAC2HDAC8 | |
| Acetic Acid SCHEMBL1229506 | 0.93 | KDM4E (0.39) | KDM4EGAAGABRA1GABRB2MEN1 | |
| Acetic Acid SCHEMBL1228444 | 0.91 | KDM4E (0.38) | KDM4EGAAGABRA1GABRB2 | |
| Acetic Acid SCHEMBL1230077 | 0.90 | KDM4E (0.49) | KDM4EGAAGABRA1GABRB2MEN1 | |
| Acetic Acid SCHEMBL1228990 | 0.87 | CYP2C9 (0.39) | KDM4EGAAMEN1KMT2AHDAC4 | |
| Acetic Acid SCHEMBL1228299 | 0.86 | KDM4E (0.37) | KDM4EHDAC4HDAC2HDAC8 | |
| Acetic Acid SCHEMBL1229082 | 0.86 | KDM4E (0.37) | KDM4EHDAC4HDAC2HDAC8 | |
| Acetic Acid SCHEMBL1229249 | 0.86 | KDM4E (0.37) | KDM4EHDAC4HDAC2HDAC8 | |
| Acetic Acid SCHEMBL1227676 | 0.85 | KDM4E (0.37) | KDM4EGAAGABRA1GABRB2MEN1 | |
| Acetic Acid SCHEMBL1229912 | 0.85 | MAPT (0.41) | KDM4EGAAGABRA1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110040070-A1 | ISOTACTIC POLY(ALKYLENE OXIDE) AND PRODUCTION PROCESS THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-02-17 | — | — | US | disclosed |