Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.44 |
| ▸ | CASP1 | P29466 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | CASP7 | P55210 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12284542 | 0.88 | RIPK2 (0.66) | RIPK2ALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL14616779 | 0.86 | RIPK2 (0.72) | RIPK2ALDH1A1CYP1A2HSD17B10CASP1 | |
| SCHEMBL14616781 | 0.84 | RIPK2 (0.64) | RIPK2ALDH1A1CYP1A2HSD17B10CASP1 | |
| SCHEMBL14616778 | 0.82 | RIPK2 (0.62) | RIPK2ALDH1A1CYP1A2HSD17B10CASP1 | |
| SCHEMBL2554274 | 0.82 | RIPK2 (0.45) | RIPK2ALDH1A1CYP1A2HSD17B10CASP1 | |
| SCHEMBL14616777 | 0.82 | RIPK2 (0.67) | RIPK2HSD17B10HPGDCASRKDM4E | |
| SCHEMBL14616773 | 0.81 | RIPK2 (0.83) | RIPK2KDM4E | |
| SCHEMBL14616775 | 0.80 | RIPK2 (0.84) | RIPK2 | |
| SCHEMBL14616784 | 0.79 | RIPK2 (0.71) | RIPK2 | |
| SCHEMBL14616776 | 0.79 | RIPK2 (0.78) | RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123609-A1 | IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-10-06 | — | — | WO | disclosed |