Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 9/20 | 0.44 |
| ▸ | JAK3 | P52333 | 8/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.44 |
| ▸ | APP | P05067 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12127997 | 0.92 | GALR2 (0.49) | SCN9AJAK2JAK3PTK2MAPT | |
| SCHEMBL12284976 | 0.86 | MAPT (0.49) | SCN9AMAPTLMNATHRBTP53 | |
| SCHEMBL12128251 | 0.85 | APP (0.62) | SCN9AJAK2JAK3PTK2APP | |
| SCHEMBL12129676 | 0.84 | APP (0.55) | JAK2APP | |
| SCHEMBL12288140 | 0.83 | SCN9A (0.46) | SCN9AJAK2JAK3PTK2LMNA | |
| SCHEMBL12131793 | 0.83 | SCN9A (0.53) | SCN9AAPP | |
| SCHEMBL12128397 | 0.81 | APP (0.53) | SCN9AAPPMAPTTP53 | |
| SCHEMBL12128012 | 0.81 | GALR2 (0.47) | SCN9AJAK2JAK3PTK2MAPT | |
| SCHEMBL12129153 | 0.79 | APP (0.69) | JAK2JAK3PTK2APP | |
| SCHEMBL12127688 | 0.79 | SCN9A (0.52) | SCN9AJAK2JAK3MAPTJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011128455-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE S.A. (CH) | 2011-10-20 | — | — | WO | disclosed |