Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.73 |
| ▸ | HTR1D | P28221 | 11/20 | 0.59 |
| ▸ | HTR1B | P28222 | 11/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | HTR1F | P30939 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12131788 | 1.00 | APP (0.73) | APPHTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL21088241 | 0.92 | APP (0.66) | APPHTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL21088993 | 0.90 | APP (0.58) | APPHTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL12285739 | 0.86 | NPC1 (0.59) | APPHTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL12128259 | 0.86 | APP (0.67) | APP | |
| SCHEMBL12129654 | 0.85 | APP (1.00) | APPHTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL12128861 | 0.84 | APP (0.49) | APP | |
| SCHEMBL8120106 | 0.83 | HTR1D (0.49) | APPHTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL12286562 | 0.83 | APP (0.61) | APPHTR1DHTR1AHTR1F | |
| SCHEMBL12285736 | 0.82 | APP (0.55) | APPHTR1DHTR1BHTR1AHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011128455-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE S.A. (CH) | 2011-10-20 | — | — | WO | disclosed |