Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 11/20 | 0.48 |
| ▸ | CCR5 | P51681 | 7/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2427818 | 0.92 | TACR1 (0.39) | TACR1SLC6A4KCNH2 | |
| SCHEMBL12290256 | 0.90 | TACR1 (0.50) | TACR1CCR5SLC6A4KCNH2OPRD1 | |
| SCHEMBL2427066 | 0.89 | TACR1 (0.49) | TACR1CCR5SLC6A4KCNH2OPRD1 | |
| SCHEMBL12290246 | 0.85 | TACR1 (0.56) | TACR1CCR5SLC6A4OPRD1OPRK1 | |
| SCHEMBL12290255 | 0.85 | TACR1 (0.45) | TACR1CCR5SLC6A4KCNH2OPRD1 | |
| SCHEMBL2431503 | 0.81 | TACR1 (0.40) | TACR1SLC6A4KCNH2 | |
| SCHEMBL2426271 | 0.81 | TACR1 (0.39) | TACR1SLC6A4KCNH2 | |
| SCHEMBL2431375 | 0.80 | TACR1 (0.51) | TACR1SLC6A4KCNH2 | |
| SCHEMBL12290356 | 0.80 | TACR1 (0.39) | TACR1CCR5SLC6A4KCNH2KLKB1 | |
| SCHEMBL3925731 | 0.79 | TACR1 (0.43) | TACR1SLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026257-B2 | Substituted heterocyclic ethers and their use in CNS disorders | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-09-27 | — | — | US | disclosed |
| US-20090018132-A1 | Substituted Heterocyclic Ethers and Their Use in CNS Disorders | BRISTOL-MYERS SQUIBB COMPANY | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018132-A1 | Substituted Heterocyclic Ethers and Their Use in CNS Disorders | CNR1, CNR2, PMP22 | TACR1 835/4885CCR5 1343/4885SLC6A4 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.