Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12035265 | 0.91 | GSK3A (0.52) | MAP2K4ALDH1A1SMN1; SMN2GSK3AGSK3B | |
| SCHEMBL11939378 | 0.87 | MAP2K4 (0.47) | MAP2K4ALDH1A1SMN1; SMN2GSK3AGSK3B | |
| SCHEMBL12054045 | 0.83 | ALK (0.41) | MAP2K4ALDH1A1SMN1; SMN2GSK3AGSK3B | |
| SCHEMBL4352331 | 0.80 | MAP2K4 (0.48) | MAP2K4GSK3AGSK3BMKNK2TTK | |
| SCHEMBL11939489 | 0.79 | FGFR4 (0.46) | MAP2K4GSK3AGSK3BALKMAPT | |
| SCHEMBL4348258 | 0.79 | MEN1 (0.47) | ALDH1A1SMN1; SMN2GSK3AGSK3BADORA2A | |
| SCHEMBL4344680 | 0.77 | JAK3 (0.48) | ALDH1A1SMN1; SMN2MAPTKDM4ETTK | |
| SCHEMBL12288537 | 0.76 | GSK3B (0.42) | MAP2K4ALDH1A1GSK3AGSK3BALK | |
| SCHEMBL13329926 | 0.76 | AURKB (0.51) | ALDH1A1GSK3AGSK3BALKADORA2A | |
| SCHEMBL30675639 | 0.76 | AURKB (0.51) | ALDH1A1GSK3AGSK3BALKADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364702-A2 | Kinase inhibitors for preventing or treating pathogen infection and method of use thereof | Emory University (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2008005877-A2 | INHIBITORS OF C-KIT AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2008-01-10 | — | — | WO | disclosed |