Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.39 |
| ▸ | JAK2 | O60674 | 16/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372302 | 0.89 | TYK2 (0.47) | TYK2JAK2 | |
| SCHEMBL2372014 | 0.87 | TYK2 (0.49) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2371085 | 0.82 | TYK2 (0.43) | TYK2JAK2 | |
| SCHEMBL12295108 | 0.82 | TYK2 (0.40) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2372683 | 0.78 | TYK2 (0.62) | TYK2JAK2RECQL | |
| SCHEMBL2371806 | 0.77 | TYK2 (0.65) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL12294605 | 0.77 | TYK2 (0.50) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2371406 | 0.77 | TYK2 (0.52) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2371784 | 0.76 | TYK2 (0.55) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2371615 | 0.76 | TYK2 (0.42) | TYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011113802-A2 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-22 | — | — | WO | disclosed |