Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 20/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12296971 | 1.00 | CFTR (0.87) | CFTR | |
| Icenticaftor SCHEMBL2371843 | 0.93 | CFTR (1.00) | CFTR | |
| Icenticaftor SCHEMBL2371948 | 0.93 | CFTR (1.00) | CFTR | |
| Icenticaftor SCHEMBL29368619 | 0.93 | CFTR (1.00) | CFTR | |
| Icenticaftor SCHEMBL2372751 | 0.93 | CFTR (1.00) | CFTR | |
| Icenticaftor SCHEMBL29365703 | 0.93 | CFTR (1.00) | CFTR | |
| SCHEMBL12296162 | 0.89 | CFTR (0.76) | CFTR | |
| SCHEMBL2370794 | 0.87 | CFTR (0.81) | CFTR | |
| SCHEMBL30784666 | 0.87 | CFTR (0.81) | CFTR | |
| SCHEMBL22791077 | 0.86 | CFTR (0.87) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011113894-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF | NOVARTIS AG (CH) | 2011-09-22 | — | — | WO | disclosed |