Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LONP1 | P36776 | 6/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.49 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.49 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.49 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.49 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.49 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.49 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.49 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.49 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.49 |
| ▸ | PSMB4 | P28070 | 3/20 | 0.49 |
| ▸ | PSMB6 | P28072 | 3/20 | 0.49 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.49 |
| ▸ | PSMB3 | P49720 | 3/20 | 0.49 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.49 |
| ▸ | PSMA6 | P60900 | 3/20 | 0.49 |
| ▸ | PSMA8 | Q8TAA3 | 3/20 | 0.49 |
| ▸ | PSMB7 | Q99436 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12194990 | 0.88 | LONP1 (0.48) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL463940 | 0.88 | LONP1 (0.60) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL30170152 | 0.86 | LONP1 (0.59) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL5837260 | 0.82 | LONP1 (0.60) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL21968901 | 0.82 | LONP1 (0.60) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL10255381 | 0.81 | LONP1 (0.53) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL15289004 | 0.79 | LONP1 (0.51) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL8306179 | 0.78 | LONP1 (0.58) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL463938 | 0.77 | LONP1 (0.65) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL14325308 | 0.77 | LONP1 (0.65) | LONP1PSMB5PSMB11PSMA7PSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2368878-A1 | Peptidomimetic protease inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-28 | — | — | EP | disclosed |