Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tropolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DBH | P09172 | 3/20 | 0.76 |
| ▸ | MMP2 | P08253 | 1/20 | 0.76 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tropolone SCHEMBL19520627 | 0.88 | DBH (0.80) | DBHMMP2HDAC4HDAC2HDAC8 | |
| Tropolone SCHEMBL19475871 | 0.87 | DBH (0.89) | DBHMMP2HDAC4HDAC2HDAC8 | |
| Tropolone SCHEMBL42739 | 0.87 | — | — | |
| Tropolone SCHEMBL16910519 | 0.85 | DBH (0.94) | DBHMMP2HDAC4HDAC2HDAC8 | |
| Tropolone SCHEMBL5969452 | 0.85 | DBH (0.94) | DBHMMP2HDAC4HDAC2HDAC8 | |
| Tropolone SCHEMBL9643338 | 0.85 | DBH (0.94) | DBHMMP2HDAC4HDAC2HDAC8 | |
| Tropolone SCHEMBL9644163 | 0.85 | DBH (0.94) | DBHMMP2HDAC4HDAC2HDAC8 | |
| Tropolone SCHEMBL29029471 | 0.85 | DBH (0.94) | DBHMMP2HDAC4HDAC2HDAC8 | |
| Tropolone SCHEMBL9643396 | 0.85 | DBH (0.94) | DBHMMP2HDAC4HDAC2HDAC8 | |
| Tropolone SCHEMBL9644286 | 0.85 | DBH (0.94) | DBHMMP2HDAC4HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210212318-A1 | CLEANSER COMPOSITIONS AND METHODS FOR USING THE SAME | MEDTECH PRODUCTS INC. | 2021-07-15 | — | — | US | disclosed |
| US-20200383326-A1 | CLEANSER COMPOSITIONS AND METHODS FOR USING THE SAME | MEDTECH PRODUCTS INC. | 2020-12-10 | — | — | US | disclosed |
| EP-3363425-A1 | CLEANSER COMPOSITIONS AND METHODS FOR USING THE SAME | Advanced Vision Research, Inc. (US) | 2018-08-22 | — | — | EP | disclosed |
| EP-2424374-B1 | CLEANSER COMPOSITIONS AND METHODS FOR USING THE SAME | ADVANCED VISION RES INC (US) | 2018-01-17 | — | — | EP | disclosed |
| US-20160095312-A1 | CLEANSER COMPOSITIONS AND METHODS FOR USING THE SAME | AKORN OPERATING COMPANY LLC | 2016-04-07 | — | — | US | disclosed |
| US-9050288-B2 | Cleanser compositions and methods for using the same | ADVANCED VISION RESEARCH, INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-20150057364-A1 | CLEANSER COMPOSITIONS AND METHODS FOR USING THE SAME | AKORN OPERATING COMPANY LLC | 2015-02-26 | — | — | US | disclosed |
| US-8932653-B2 | Cleanser compositions and methods for using the same | ADVANCED VISION RESEARCH, INC. (US) | 2015-01-13 | — | — | US | disclosed |
| US-20130236579-A1 | CLEANSER COMPOSITIONS AND METHODS FOR USING THE SAME | ADVANCED VISION RESEARCH, INC. (US) | 2013-09-12 | — | — | US | disclosed |
| US-8449928-B2 | Cleanser compositions and methods for using the same | ADVANCED VISION RESEARCH, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-20120288575-A1 | CLEANSER COMPOSITIONS AND METHODS FOR USING THE SAME | ADVANCED VISION RESEARCH, INC. (US) | 2012-11-15 | — | — | US | disclosed |
| US-8231912-B2 | Cleanser composition and methods for using the same | ADVANCED VISION RESEARCH, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| EP-2424374-A1 | CLEANSER COMPOSITIONS AND METHODS FOR USING THE SAME | Advanced Vision Research, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| US-20100285155-A1 | CLEANSER COMPOSITION AND METHODS FOR USING THE SAME | ADVANCED VISION RESEARCH, INC. (US) | 2010-11-11 | — | — | US | disclosed |
| WO-2010127227-A1 | CLEANSER COMPOSITIONS AND METHODS FOR USING THE SAME | ADVANCED VISION RESEARCH, INC. (US) | 2010-11-04 | — | — | WO | disclosed |