Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 18/20 | 0.72 |
| ▸ | JAK2 | O60674 | 15/20 | 0.72 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12295212 | 0.89 | TYK2 (0.58) | TYK2JAK2KDR | |
| SCHEMBL2372952 | 0.89 | TYK2 (0.58) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL12295203 | 0.89 | TYK2 (0.56) | TYK2JAK2KDR | |
| SCHEMBL2372016 | 0.88 | TYK2 (0.57) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2371723 | 0.88 | TYK2 (0.55) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL12294563 | 0.88 | TYK2 (0.55) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2371388 | 0.84 | TYK2 (0.72) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2372339 | 0.83 | TYK2 (0.70) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2372652 | 0.83 | TYK2 (0.51) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2371706 | 0.81 | TYK2 (0.48) | TYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011113802-A2 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-22 | — | — | WO | disclosed |