Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.70 |
| ▸ | JAK2 | O60674 | 18/20 | 0.70 |
| ▸ | JAK1 | P23458 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2384490 | 0.91 | TYK2 (0.67) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL14858119 | 0.91 | JAK2 (0.67) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2385184 | 0.88 | TYK2 (0.63) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2386555 | 0.88 | TYK2 (0.70) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL14858524 | 0.87 | TYK2 (0.55) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL12294744 | 0.87 | JAK2 (0.62) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2382823 | 0.86 | JAK2 (0.61) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2372732 | 0.82 | TYK2 (0.64) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2372339 | 0.80 | TYK2 (0.70) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL2382309 | 0.80 | TYK2 (0.54) | TYK2JAK2JAK1CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011113802-A2 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-22 | — | — | WO | disclosed |