Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.83 |
| ▸ | SRC | P12931 | 6/20 | 0.83 |
| ▸ | PKMYT1 | Q99640 | 3/20 | 0.83 |
| ▸ | BCR | P11274 | 3/20 | 0.83 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.83 |
| ▸ | EGFR | P00533 | 2/20 | 0.83 |
| ▸ | LCK | P06239 | 2/20 | 0.83 |
| ▸ | FYN | P06241 | 2/20 | 0.83 |
| ▸ | CSF1R | P07333 | 2/20 | 0.83 |
| ▸ | YES1 | P07947 | 2/20 | 0.83 |
| ▸ | LYN | P07948 | 2/20 | 0.83 |
| ▸ | RET | P07949 | 2/20 | 0.83 |
| ▸ | HCK | P08631 | 2/20 | 0.83 |
| ▸ | KIT | P10721 | 2/20 | 0.83 |
| ▸ | BRAF | P15056 | 2/20 | 0.83 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.83 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.83 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.83 |
| ▸ | EPHA8 | P29322 | 2/20 | 0.83 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13378598 | 0.94 | ABL1 (0.89) | ABL1SRCPKMYT1BCREPHB6 | |
| SCHEMBL31634945 | 0.94 | ABL1 (0.89) | ABL1SRCPKMYT1BCREPHB6 | |
| SCHEMBL21350067 | 0.92 | ABL1 (0.86) | ABL1SRCPKMYT1BCREPHB6 | |
| SCHEMBL28426331 | 0.92 | ABL1 (0.84) | ABL1SRCPKMYT1BCREPHB6 | |
| SCHEMBL28427234 | 0.92 | ABL1 (0.84) | ABL1SRCPKMYT1BCREPHB6 | |
| SCHEMBL14153376 | 0.91 | ABL1 (0.83) | ABL1SRCPKMYT1BCREPHB6 | |
| Dasatinib Anhydrous SCHEMBL8226 | 0.91 | ABL1 (1.00) | ABL1SRCPKMYT1BCREPHB6 | |
| Dasatinib Anhydrous SCHEMBL29381185 | 0.91 | ABL1 (1.00) | ABL1SRCPKMYT1BCREPHB6 | |
| Dasatinib Anhydrous SCHEMBL28350326 | 0.91 | ABL1 (1.00) | ABL1SRCPKMYT1BCREPHB6 | |
| Dasatinib Anhydrous SCHEMBL1705152 | 0.90 | ABL1 (0.98) | ABL1SRCPKMYT1BCREPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019173224-A1 | DEUTERATED COMPOUNDS AND CHIMERAS AND USES THEREOF | BIOTHERYX, INC. (US) | 2019-09-12 | — | — | WO | disclosed |
| US-20110212475-A1 | Fluorescently Or Spin-Labeled Kinases For Rapid Screening And Identification Of Novel Kinase Inhibitor Scaffolds | MAX-PLANCK GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2011-09-01 | — | — | US | disclosed |