SCHEMBL12299544

SCHEMBL12299544

COC(=O)c1ccc(C(=O)OC)c(N/N=C(/C(C)=O)C(=O)Nc2ccc(C(=O)O)cc2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 15/20 0.48
ALDH1A1 P00352 12/20 0.48
HPGD P15428 5/20 0.48
HSD17B10 Q99714 4/20 0.48
CASP1 P29466 1/20 0.48
CASP7 P55210 1/20 0.48
ATM Q13315 2/20 0.46
GAA P10253 4/20 0.45
GLA P06280 2/20 0.45
MAPT P10636 6/20 0.43
SMN1; SMN2 Q16637 5/20 0.43
NPC1 O15118 4/20 0.43
RAB9A P51151 4/20 0.43
KMT2A Q03164 1/20 0.43
MAPK1 P28482 1/20 0.42
LMNA P02545 1/20 0.42
NFKB1 P19838 1/20 0.42
NFKB2 Q00653 1/20 0.42
RELA Q04206 1/20 0.42
TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12677172 0.98 KDM4E (0.48) KDM4EALDH1A1HPGDHSD17B10CASP1
SCHEMBL15246775 0.96 KDM4E (0.48) KDM4EALDH1A1HPGDHSD17B10CASP1
SCHEMBL16523 0.95 KDM4E (0.52) KDM4EALDH1A1HPGDHSD17B10CASP1
SCHEMBL10052753 0.95 KDM4E (0.52) KDM4EALDH1A1HPGDHSD17B10CASP1
SCHEMBL11913349 0.92 KDM4E (0.45) KDM4EALDH1A1HPGDHSD17B10CASP1
SCHEMBL765445 0.92 KDM4E (0.51) KDM4EALDH1A1HPGDHSD17B10CASP1
SCHEMBL14960667 0.91 KDM4E (0.48) KDM4EALDH1A1HPGDHSD17B10CASP1
SCHEMBL12393179 0.91 KDM4E (0.48) KDM4EALDH1A1HPGDHSD17B10CASP1
SCHEMBL13092164 0.91 KDM4E (0.48) KDM4EALDH1A1HPGDHSD17B10CASP1
SCHEMBL13111768 0.91 KDM4E (0.48) KDM4EALDH1A1HPGDHSD17B10CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8022117-B2 Non-aqueous pigment dispersions containing specific dispersion synergists AGFA GRAPHICS NV (BE) 2011-09-20 US disclosed
US-8022117-B2 Non-aqueous pigment dispersions containing specific dispersion synergists AGFA GRAPHICS NV (BE) 2011-09-20 US disclosed
US-7704312-B2 Non-aqueous pigment dispersions containing specific dispersion synergists AGFA GRAPHICS NV (BE) 2010-04-27 US disclosed
US-7704312-B2 Non-aqueous pigment dispersions containing specific dispersion synergists AGFA GRAPHICS NV (BE) 2010-04-27 US disclosed
US-20080312358-A1 Non-Aqueous Pigment Dispersions Containing Specific Dispersion Synergists AGFA GRAPHICS NV (BE) 2008-12-18 US disclosed
US-20080312358-A1 Non-Aqueous Pigment Dispersions Containing Specific Dispersion Synergists AGFA GRAPHICS NV (BE) 2008-12-18 US disclosed
US-20080308004-A1 Non-Aqueous Pigment Dispersions Containing Specific Dispersion Synergists AGFA GRAPHICS NV (BE) 2008-12-18 US disclosed
US-20080308004-A1 Non-Aqueous Pigment Dispersions Containing Specific Dispersion Synergists AGFA GRAPHICS NV (BE) 2008-12-18 US disclosed