Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.61 |
| ▸ | JAK2 | O60674 | 10/20 | 0.61 |
| ▸ | JAK1 | P23458 | 10/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12333200 | 1.00 | JAK3 (0.61) | JAK3JAK2JAK1MAPK1SYK | |
| SCHEMBL2377964 | 0.90 | JAK1 (0.60) | JAK3JAK2JAK1MAPK1 | |
| SCHEMBL12333199 | 0.88 | JAK3 (0.57) | JAK3JAK2JAK1MAPK1SYK | |
| SCHEMBL12332955 | 0.88 | JAK3 (0.57) | JAK3JAK2JAK1MAPK1SYK | |
| SCHEMBL12299968 | 0.87 | JAK3 (0.62) | JAK3JAK2JAK1MAPK1SYK | |
| SCHEMBL2378559 | 0.85 | JAK1 (0.62) | JAK3JAK2JAK1MAPK1SYK | |
| SCHEMBL2377070 | 0.85 | JAK3 (0.60) | JAK3JAK2JAK1MAPK1SYK | |
| SCHEMBL12333270 | 0.83 | JAK2 (0.51) | JAK3JAK2JAK1MAPK1SYK | |
| SCHEMBL12299590 | 0.83 | JAK2 (0.51) | JAK3JAK2JAK1MAPK1SYK | |
| SCHEMBL2379800 | 0.82 | JAK2 (0.72) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | disclosed |
| WO-2011117145-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-29 | — | — | WO | disclosed |
| US-20110230462-A1 | Pyrrolopyrazine Kinase Inhibitors | HENDRICKS ROBERT THAN | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230462-A1 | Pyrrolopyrazine Kinase Inhibitors | SYK, ZAP70, BTK | JAK3 13/4885JAK2 5/4885JAK1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.